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A double-blind, placebo-controlled trial exploring the efficacy of nortriptyline and amantadine in the management of post-traumatic agitation

Objective: Test the efficacy of two medications, amantadine and nortriptyline, to control agitation.

Subjects: Persons receiving rehabilitation for TBI who met all inclusion and exclusion criteria.

Design: Double-blind, randomized, placebo-controlled clinical trial. Both agitation and cognition were monitored during the trial.

Current status: Data collection has been completed.

Registry Project Number: 408
Lead Investigator: Mysiw, W
Lead Center for Project: Ohio State University
Collaborating Investigators: Fugate, L, Bogner, J, Glenn, M
Collaborating Institutions: Spaulding Rehabilitation Hospital
Date of Completion: 12/30/2004
Type: National - Separately Funded
Status of Project: Latest Information Shown

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