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Apolipoprotein E and Cognitive Outcome Following Moderate and Severe Traumatic Brain Injury

Objective: To examine the relationship between the Apolipoprotein E (APOE) 4 allele and cognitive outcome in traumatic brain injured (TBI) patients. It was predicted that the carriers would exhibit significantly poorer cognitive outcomes.

Participants: Seventy-four TBI patients 16-59 years old were examined at discharge from inpatient rehabilitation programs. Thirty-nine patients were reassessed at one year follow-up.

Settings: Rehabilitation programs at Emory University School of Medicine and Shepherd Center in Atlanta, Georgia, and the Mayo Clinic College of Medicine in Rochester, Minnesota.

Methods: Neuropsychological assessments of attention, language, memory, visuoanalytic skills, and executive functioning were performed.

Results: The 4 positive and negative patients were comparable in demographics, length of rehabilitation stay, injury-test intervals, and severity of injury. Cognitive scores did not significantly differ between the groups at either test occasion.

Conclusions: These results do not suggest a significant relationship between APOE 4 and cognitive outcome from TBI.

Registry Project Number: 425
Lead Investigator: Goldstein, F
Lead Center for Project: Mayo Medical Center
Collaborating Investigators: Stringer, A, Malec, J, Gearing, M, Moessner, A, Greenspan, A, Macciocchi, S
Date of Completion: 09/16/2004
Type: Local
Status of Project: Latest Information Shown

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