Projects of the TBINDC Registry by Research Center
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6 project available at this time for JFK Johnson Rehabilitation Institute
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| Investigating the Utility of Functional MRI in Assessing Cognition, Predicting Outcome and Planning Treatment in Persons Diagnosed with Minimally Conscious State. | ||
| Abstract: The minimally conscious state (MCS) is a recently-defined state of altered consciousness characterized by inconsistent but clearly recognizable behavioral signs of consciousness. Recent functional neuroimaging studies suggest that persons in MCS may retain functional cortical networks capable of supporting complex cognitive functions. In combination with other sources of clinical data, fMRI may also help identify those individuals with severe TBI who are most likely to benefit from rehabilitative interventions. This study will conduct neurobehavioral and fMRI investigations of 15 patients diagnosed with MCS, compare the activation maps with those from neurologically normal control subjects, examine the relationship between neurobehavioral... more | ||
| Investigators: | Giacino J, Kalmar K, McCagg C | view full details |
| Lead Center: | JFK Johnson Rehabilitation Institute | |
| Feasibility of administration of a brief neuropsychological battery for use during acute inpatient rehabilitation after TBI | ||
| Abstract: Previous investigations have studied the association of early neuropsychological test performance with late outcome in patients who were initially evaluated during inpatient rehabilitation. However, in these previous investigations, neuropsychological test findings have been confounded with patient injury severity. Neuropsychological assessment was performed at resolution of PTA and PTA duration is a well-recognized index of injury severity. Clinical experience would suggest that a patient who reaches a given level of neuropsychological functioning at one month post injury will have a better long term outcome than another patient who takes 3 months to reach the same level of neuropsychological functioning. By basing timing of testing... more | ||
| Investigators: | Kalmar K, Giacino J, Novack T, Sherer M, Nakase-Thompson R, Frol A, Hanks R, Millis S, Gordon W, Ricker J | view full details |
| Lead Center: | JFK Johnson Rehabilitation Institute | |
| Collaborating Centers: | University of Alabama, Methodist Rehabilitation Center, North Texas Traumatic Brain Injury Model System, Rehabilitation Institute of Michigan, Mount Sinai School of Medicine, University of Pittsburgh | |
| A Prospective Controlled Study of Integrated Cognitive-Psychosocial Rehabilitation with ‘Standard' Neurorehabilitation for Persons with Traumatic Brain Injury. | ||
| Abstract: Neuropsychological rehabilitation of persons with traumatic brain injury may best be achieved through a comprehensive, holistic approach to the treatment of cognitive, emotional, and functional impairments and disability. Participants with TBI who are recruited from clinical and community referrals will be randomly assigned to received either an intensive-holistic program of cognitive rehabilitation or a "standard" neurorehabilitation program. The primary outcome measure is the number of subjects demonstrating clinically significant changes in community integrations after treatment. This study will also incorporate measures of neuropsychological functioning and subjective well-being as indicators of rehabilitation outcome.... more |
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| Investigators: | Cicerone K, Mott T, Azulay J, Friel J | view full details |
| Lead Center: | JFK Johnson Rehabilitation Institute | |
| What Does it Take to Live a Full, and Fulfilling, Life? Qualitative and Quantitative Assessment of Quality of Life in Persons with TBI. | ||
| Abstract: Given the considerable variability that characterizes the long-term outcomes of persons with TBI, it is apparent that a full understanding of the factors that contribute to a full and fulfilling life will require measurement and intervention strategies that are sensitive to the unique experiences of each individual. This study will investigate quality of life from the perspective of the individual with TBI, using a combination of qualitative and quantitative methods. ... more |
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| Investigators: | Cicerone K, Azulay J | view full details |
| Lead Center: | JFK Johnson Rehabilitation Institute | |
| A Multicenter Prospective Randomized Controlled Trial of the Effectiveness of Amantadine Hydrochloride in Promoting Recovery of Function Following Severe Traumatic Brain Injury | ||
| Abstract: Severe traumatic brain injury may result in severe disorders of consciousness (DOC), including coma, the vegetative state (VS) and the minimally conscious state (MCS). The longer the duration of impaired consciousness, the worse the ultimate functional prognosis, with only about half of those individuals who remain unconscious for a month post-TBI regaining consciousness within a year. The severe functional disability associated with prolonged DOC places enormous emotional, financial, ethical, and logistical strains on caregivers and major resource demands on society. Numerous treatments have been recommended to hasten the return of consciousness or improve the ultimate level of recovery, including various psychotropic drugs, "coma... more | ||
| Investigators: | Giacino J, Whyte J, Kalmar K, Yablon S, Sherer M, Bagiella E, Murathe S, Singh V, Long D, Murphy E, Merges B, Eifert B, Mauer P, Katz D, Edelstein M, Novak P, Wright L, Van Wie S, Childs N, Mercer W | view full details |
| Lead Center: | JFK Johnson Rehabilitation Institute | |
| Collaborating Centers: | Moss Rehabilitation Research Institute, Methodist Rehabilitation Center | |
| A Prospective Observational Study of Screening and Prophylaxis for Deep Vein Thrombosis in Survivors of Traumatic Brain Injury During Inpatient Rehabilitation | ||
| Abstract: During the period of acute rehabilitation for traumatic brain injury (TBI), the development of deep vein thrombosis (DVT) is a significant complication that increases morbidity and mortality. Pulmonary embolism (PE) is one of the most ominous, and frequently life-threatening, complications that occur during TBI rehabilitation. TBI patients often sustain concomitant multiple trauma and have cumulative risk factors for DVT. Because these TBI patients are usually maintained at bed rest during their acute hospitalization, they are at increased risk for existing DVT to embolize when they enter the rehabilitation setting and resume mobility. Prior to initiating this study, a practice survey was distributed to the 16 rehabilitation centers of... more | ||
| Investigators: | Carlile M, Diaz-Arrastia R, Mysiw W | view full details |
| Lead Center: | North Texas Traumatic Brain Injury Model System | |
| Collaborating Centers: | Carolinas Rehabilitation, JFK Johnson Rehabilitation Institute, Mayo Medical Center, Mount Sinai School of Medicine, Santa Clara Valley Medical Center, Methodist Rehabilitation Center, Ohio State University, University of Alabama, University of Pittsburgh | |
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6 project available at this time for JFK Johnson Rehabilitation Institute
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