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Projects of the TBINDC Registry by Research Center
4 projects available at this time for North Texas Traumatic Brain Injury Model System

A Prospective Observational Study of Screening and Prophylaxis for Deep Vein Thrombosis in Survivors of Traumatic Brain Injury During Inpatient Rehabilitation
Abstract: During the period of acute rehabilitation for traumatic brain injury (TBI), the development of deep vein thrombosis (DVT) is a significant complication that increases morbidity and mortality. Pulmonary embolism (PE) is one of the most ominous, and frequently life-threatening, complications that occur during TBI rehabilitation. TBI patients often sustain concomitant multiple trauma and have cumulative risk factors for DVT. Because these TBI patients are usually maintained at bed rest during their acute hospitalization, they are at increased risk for existing DVT to embolize when they enter the rehabilitation setting and resume mobility. Prior to initiating this study, a practice survey was distributed to the 16 rehabilitation centers of... more
Investigators: Carlile M, Diaz-Arrastia R, Mysiw W view full
Lead Center: North Texas Traumatic Brain Injury Model System
Collaborating Centers: Carolinas Rehabilitation, JFK Johnson Rehabilitation Institute, Mayo Medical Center, Mount Sinai School of Medicine, Santa Clara Valley Medical Center, Methodist Rehabilitation Center, Ohio State University, University of Alabama, University of Pittsburgh
Genetic Factors in Outcome after Traumatic Brain Injury
Abstract: Recognized factors such as severity of the initial injury, age, or the occurrence of complications during the acute hospitalization are imperfect predictors of outcome after TBI (Jennett, Teasdale, et al. 1979; Dikmen, Temkin, et al. 1987; Dikmen, Ross, et al. 1995; Vollmer, Torner, et al. 1991). Recently, the possibility that genetic factors may influence functional outcome after TBI has been supported by the finding from several independent groups that inheritance of the APOE-e4 allele increases the risk of poor neurologic recovery (Teasdale, Nicoll, et al. 1997; Sorbi, Nacmias, et al. 1995; Friedman, Froom, et al. 1999; Jordan, Relkin, et al. 1997). Recent progress in the Human Genome Project has identified common polymorphisms in a... more
Investigators: Diaz-Arrastia R, Carlile M, Frol A, Hudak A, Harper C, Wren T, Caesar R, Booker K view full
Lead Center: North Texas Traumatic Brain Injury Model System
Evaluation of Diffuse Axonal Injury in patients with Traumatic Brain Injury Using Diffusion Tensor Imaging
Abstract: Abstract:
Diffuse Axonal Injury (DAI) results from high velocity deceleration and shear strain and is believed to be the predominant mechanism of injury in 40 – 50% of TBIs requiring hospital admission in the US. Diffusion Tensor Magnetic Resonance Imaging (DTI) is a novel imaging technique considered to be a more reliable indicator of DAI than standard structural MRI. DAI is difficult to determine from usual CT scans and, while structural MRI scanning may add some sensitivity, current neuroimaging methods have not been associated with severity of injury or predictive of outcome. The anatomy and integrity of white matter fiber tracts can be determined non-invasively with DTI, providing new information about brain networks and... more
Investigators: Diaz-Arrastia R, Hudak A, Carlile M view full
Lead Center: North Texas Traumatic Brain Injury Model System
Feasibility of administration of a brief neuropsychological battery for use during acute inpatient rehabilitation after TBI
Abstract: Previous investigations have studied the association of early neuropsychological test performance with late outcome in patients who were initially evaluated during inpatient rehabilitation. However, in these previous investigations, neuropsychological test findings have been confounded with patient injury severity. Neuropsychological assessment was performed at resolution of PTA and PTA duration is a well-recognized index of injury severity. Clinical experience would suggest that a patient who reaches a given level of neuropsychological functioning at one month post injury will have a better long term outcome than another patient who takes 3 months to reach the same level of neuropsychological functioning. By basing timing of testing... more
Investigators: Kalmar K, Giacino J, Novack T, Sherer M, Nakase-Thompson R, Frol A, Hanks R, Millis S, Gordon W, Ricker J view full
Lead Center: JFK Johnson Rehabilitation Institute
Collaborating Centers: University of Alabama, Methodist Rehabilitation Center, North Texas Traumatic Brain Injury Model System, Rehabilitation Institute of Michigan, Mount Sinai School of Medicine, University of Pittsburgh
4 projects available at this time for North Texas Traumatic Brain Injury Model System

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