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Projects of the TBINDC Registry by Research Center
8 projects available at this time for Mount Sinai School of Medicine

Treatment of Post-TBI Fatigue with Modafinil
Abstract: Fatigue is associated with reduced participation in activities, reduced quality of life, health problems, and cognitive impairments in medical populations and individuals with TBI. However, little research has focused on Post-TBI Fatigue (PTBIF). The proposed project is a double-blind, randomized, placebo-controlled trial designed to examine the utility of modafinil (Provigil) as a potential treatment for PTBIF. No medications are currently FDA approved for the treatment of PTBIF, and existing treatments have been shown to have side-effects and limited effectiveness. Impact will be measured using data from self-report measures of fatigue and performance on serial neuropsychological batteries.... more
Investigators: Gordon W, Cantor J, Dijkers M, Flanagan S, Greenwald B view full
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Lead Center: Mount Sinai School of Medicine
A Study Of Post-TBI Fatigue
Abstract: Fatigue is associated with reduced participation in activities, reduced quality of life, health problems, and cognitive impairments in medical populations and individuals with TBI. However, little research has focused on Post-TBI Fatigue. This project will address this issue. The study is a three-year project designed to develop a betterl understanding of Post-TBI Fatigue and its correlates. Self-report data are collected from individuals with TBI and persons with no disability regarding fatigue and related (or hypothetically related) phenomena such as depression, pain, sleep problems, health problems, level of participation in activities, quality of life, and injury variables. In order to assess the nature of and measure the impact of... more
Investigators: Gordon W, Cantor J, Dijkers M, Flanagan S view full
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Lead Center: Mount Sinai School of Medicine
Treatment of Post-TBI Depression
Abstract: Mood disorders are very common after TBI, with both depression and anxiety disorders occurring at rates much higher than for the population at large, and having severe negative effects on participation and quality of life. This is a randomized clinical trial to determine the efficacy of sertraline (Zoloft) in the treatment of major depressive disorder (MDD) post TBI. Secondary goals are to determine the impact of sertraline on quality of life, and to explore the potential impact of sertraline on anxiety disorders post TBI. 50 subjects with MDD will be randomized to 12 weeks of treatment with Zoloft or placebo. They will complete a comprehensive battery of outcomes measures at baseline and after 12 weeks, and biweekly measures of depression... more
Investigators: Hibbard M, Cantor J, Flanagan S, Greenwald B, Gordon W, Ashman T view full
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Lead Center: Mount Sinai School of Medicine
A Prospective Observational Study of Screening and Prophylaxis for Deep Vein Thrombosis in Survivors of Traumatic Brain Injury During Inpatient Rehabilitation
Abstract: During the period of acute rehabilitation for traumatic brain injury (TBI), the development of deep vein thrombosis (DVT) is a significant complication that increases morbidity and mortality. Pulmonary embolism (PE) is one of the most ominous, and frequently life-threatening, complications that occur during TBI rehabilitation. TBI patients often sustain concomitant multiple trauma and have cumulative risk factors for DVT. Because these TBI patients are usually maintained at bed rest during their acute hospitalization, they are at increased risk for existing DVT to embolize when they enter the rehabilitation setting and resume mobility. Prior to initiating this study, a practice survey was distributed to the 16 rehabilitation centers of... more
Investigators: Carlile M, Diaz-Arrastia R, Mysiw W view full
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Lead Center: North Texas Traumatic Brain Injury Model System
Collaborating Centers: Carolinas Rehabilitation, JFK Johnson Rehabilitation Institute, Mayo Medical Center, Mount Sinai School of Medicine, Santa Clara Valley Medical Center, Methodist Rehabilitation Center, Ohio State University, University of Alabama, University of Pittsburgh
Feasibility of administration of a brief neuropsychological battery for use during acute inpatient rehabilitation after TBI
Abstract: Previous investigations have studied the association of early neuropsychological test performance with late outcome in patients who were initially evaluated during inpatient rehabilitation. However, in these previous investigations, neuropsychological test findings have been confounded with patient injury severity. Neuropsychological assessment was performed at resolution of PTA and PTA duration is a well-recognized index of injury severity. Clinical experience would suggest that a patient who reaches a given level of neuropsychological functioning at one month post injury will have a better long term outcome than another patient who takes 3 months to reach the same level of neuropsychological functioning. By basing timing of testing... more
Investigators: Kalmar K, Giacino J, Novack T, Sherer M, Nakase-Thompson R, Frol A, Hanks R, Millis S, Gordon W, Ricker J view full
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Lead Center: JFK Johnson Rehabilitation Institute
Collaborating Centers: University of Alabama, Methodist Rehabilitation Center, North Texas Traumatic Brain Injury Model System, Rehabilitation Institute of Michigan, Mount Sinai School of Medicine, University of Pittsburgh
Development of Participation Measures for People with Traumatic Brain Injury
Abstract: There is no general agreement in the field regarding a reliable and valid objective measure of community participation after TBI. This study will use a multi-center, prospective, cohort design to evaluate participation items pooled from four currently used tools: the Craig Handicap Assessment and Reporting Technique Short Form (CHART-SF); the Community Integration Questionnaire Version 2 (CIQ-2); the Participation Objective-Participation Subjective (PO-PS) section of the Living Life After TBI (LLATBI); and the Mayo-Portland Participation Index (M2PI). The primary objectives of this study are to: 1) evaluate internal consistency, concurrent validity, and item/scale structure of current measures of community participation after TBI; and 2)... more
Investigators: Whiteneck G, Bushnik T, Cicerone K, Corrigan J, Bogner J, Dijkers M, Gordon W, Hart T, Malec J, Novack T view full
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Lead Center: Craig Hospital
Collaborating Centers: University of Alabama, Santa Clara Valley Medical Center, Mayo Medical Center, Kessler Medical Rehabilitation Research and Education Corporation, Mount Sinai School of Medicine, Ohio State University, Moss Rehabilitation Research Institute
Characterizing and testing the relative efficacy of vocational rehabilitation interventions after TBI - Phase 1: Characterizing and measuring variations in vocational treatments across the TBIMS
Abstract: The ability to work is important to many persons with TBI for maximizing financial independence, achieving social re-integration and maintaining quality of life. Vocational re-entry is frequently addressed in post-acute rehabilitation of TBI, but employment remains a goal that is difficult to attain. We need ways of evaluating what the most critical elements of the treatment are, or at what intensity or duration they must be delivered. The objectives of Phase 1 are: (1) to develop definitions for content and process parameters for characterizing specific vocational interventions for TBI; (2) to use these definitions to survey the types and variations in vocational services across the TBIMS; (3) to develop testable hypotheses about... more
Investigators: Hart T, Dijkers M, Fraser R, Bogner J, Cicerone K, Malec J view full
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Lead Center: Moss Rehabilitation Research Institute
Collaborating Centers: Mayo Medical Center, Kessler Medical Rehabilitation Research and Education Corporation, Ohio State University, University of Washington, Mount Sinai School of Medicine
A Collaborative National Information Center on Outcome Measurement in Brain Injury
Abstract: In order to better serve the rehabilitation community, the Center on Outcome Measurement in Brain Injury (COMBI) website and newsletter are proposed. The COMBI provides information on measures in a format that is easily accessed and understood, free of charge, objective, and comprehensive. Each measure will have online syllabi, training and testing materials (including the measure's rating form), information on scale properties, a reference listing of published studies using the measure, and a section for "Frequently Asked Questions."... more
Investigators: Bushnik T, Wright J, Mellick D, Harrison-Felix C, Boake C, Sander A, Malec J, Sherer M, Thompson R, Novack T, Dijkers M, Bogner J, Corrigan J, Hammond F, Kreutzer J, Marwitz J, Millis S, O'Neil-Pirozzi T view full
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Lead Center: Santa Clara Valley Medical Center
Collaborating Centers: Craig Hospital, The Institute for Rehabilitation and Research, Mayo Medical Center, Methodist Rehabilitation Center, University of Alabama, Rehabilitation Institute of Michigan, Ohio State University, Carolinas Rehabilitation, Virginia Commonwealth University/Medical College of Virginia, Moss Rehabilitation Research Institute, Kessler Medical Rehabilitation Research and Education Corporation, Spaulding Rehabilitation Hospital, Mount Sinai School of Medicine
8 projects available at this time for Mount Sinai School of Medicine



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