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Projects of the TBINDC Registry by Research Center
16 project available at this time for Craig Hospital

Social Communication Skills Training in Traumatic Brain Injury: A Treatment Efficacy Study
Abstract: This study is evaluating the efficacy of a treatment program addressing social communication skills following TBI. Social communication skills are frequently impaired after a TBI, and these impairments are believed to contribute to social isolation due to difficulty in establishing and maintaining interpersonal relationships with friends, family and co-workers. Research suggests that social communication skills for individuals with TBI can be relearned through practice and repetition in functional situations. Most of the reported research in this area has been conducted using small sample sizes, with very limited use of randomized controlled studies. The actual treatment intervention for social skills used in these studies is most... more
Investigators: Dahlberg C, Newman J, Hawley L, Morey C, Harrison-Felix C, Whiteneck G view full
Lead Center: Craig Hospital
Improving prediction of rehabilitation outcomes by establishing ecological validity for neuropsychological assessment instruments
Abstract: 1. Executive Function Evaluation in Persons with Traumatic Brain Injury:
Ecological Validity of Five Neuropsychological Tests

Primary Objective: To evaluate the ecological validity of five neuropsychological tests of executive function. Research Design: Comparison of neuropsychological tests and year one post-injury outcome measures. Methods and Procedures: 51 Traumatic Brain Injury (TBI) Model System participants were administered the Controlled Word Association Test (COWAT), Ruff Figural Fluency Test (RFFT), Wisconsin Card Sorting Test (WCST), Delis-Kaplan Executive Functioning System (DKEFS) Sorting Test (DKEFS: ST), and DKEFS Twenty Questions Test (DKEFS: TQ) at one year post-injury follow-up. Outcome measures including... more
Investigators: Schraa J, Gerber D, Cusick C view full
Lead Center: Craig Hospital
Violence Related Traumatic Brain Injury: A Population- Based Study.
Abstract: Background: Most studies of traumatic brain injury (TBI) and violence are small, focus on one violent mechanism only, and are non-representative. This large, population based effort examines characteristics, circumstances of injury, treatment pathways, and outcomes of persons with TBI from all types of violence, compares them with other TBI survivors, identifies a risk-profile and examines how a violent etiology impacts later outcomes.
Methods: Medical record abstraction and telephone survey at one-year post-injury of a weighted sample of 2771 Coloradans hospitalized with TBI between January 1, 1996 and June 30, 1999.
Results: People with violently-incurred TBI are more likely to be young, male, members of minority groups, single, and... more
Investigators: Weintraub A, Gerhart K, Mellick D view full
Lead Center: Craig Hospital
Modafinil for the Treatment of Fatigue and Excessive Daytime Sleepiness in Individuals with Traumatic Brain Injury
Abstract: It is estimated that there are 5.3 million Americans living with a traumatic brain injury (TBI) related disability today. Fatigue and excessive daytime sleepiness appear to be common problems reported by individuals who have sustained TBI. These symptoms have a detrimental effect on all aspects of a person.s daily life. Modafinil is an FDA-approved wakefulness promoting agent for individuals with excessive daytime sleepiness associated with narcolepsy. It has also been found to be effective in reducing fatigue and sleepiness in persons with multiple sclerosis, fibromyalgia, Parkinson.s disease and depression. Some evidence suggests that if Modafinil is effective in reducing fatigue and sleepiness that this may lead to improved... more
Investigators: Weintraub A, Harrison-Felix C, Morey C, Jha A, Whiteneck G view full
Lead Center: Craig Hospital
Outcomes and Environmental Factors in the Decades After Traumatic Brain Injury
Abstract: While the TBI Model Systems Database has documented many of the important outcomes occurring after Traumatic Brain Injury (TBI), it is only beginning to document truly long-term outcomes. As stated in NIDRR.s Long Range Plan, the Maintenance of Health and Function and Full Access to Community Life are key outcomes of interest with particular objectives to .identify predictors of community participation. and .examine the impact of environment and attitudinal barriers on the outcomes of individuals with TBI.. This study is designed to take advantage of Craig Hospital.s four decade history of rehabilitating people with TBI, to allow a cross-sectional analysis of the changing pattern of TBI outcomes and environmental barriers occurring... more
Investigators: Whiteneck G, Brooks C, Harrison-Felix C, Gerhart K view full
Lead Center: Craig Hospital
Service Utilization, Cost, and Payor Source for Individuals with Traumatic Brain Injury in the Year Following Initial Inpatient Rehabilitation
Abstract: Objectives: To determine service utilization, costs, and payor source associated with traumatic brain injury one-year post discharge from initial rehabilitation.
Design: cost analysis of a representative cohort.
Setting: A rehabilitation hospital and community during the first year post discharge from initial rehabilitation.
Participants: 60 participants who sustained a TBI and who had an inpatient rehabilitation hospitalization.
Interventions: Not applicable.
Main Outcome Measures: Included itemized billing records of services received during inpatient rehabilitation up to one year post discharge from rehabilitation.
Results: The average per person charges totaled $40,348 in the first year post inpatient rehabilitation discharge. ... more
Investigators: Whiteneck G, Terrill M, Brooks C, Harrison-Felix C, Manley S view full
Lead Center: Craig Hospital
Identifying environmental factors that influence the outcomes of people with traumatic brain injury
Abstract: Objectives: To determine the types of environmental barriers reported by persons with traumatic brain injury (TBI) and to identify the relations between environmental barriers and such components of societal participation as employment, community mobility, social integration, and life satisfaction. Design: Seventy-three persons with TBI who were participating in the TBI Model Systems program at Craig Hospital were surveyed at 1 year, using a new measure of the environment, the Craig Hospital Inventory of Environmental Factors (CHIEF), which rates frequency and impact of 25 barriers.
Results: Transportation, the surroundings, government policies, attitudes, and the natural environment were the environmental barriers with the greatest... more
Investigators: Whiteneck G, Gerhart K, Cusick C view full
Lead Center: Craig Hospital
Development of Participation Measures for People with Traumatic Brain Injury
Abstract: There is no general agreement in the field regarding a reliable and valid objective measure of community participation after TBI. This study will use a multi-center, prospective, cohort design to evaluate participation items pooled from four currently used tools: the Craig Handicap Assessment and Reporting Technique Short Form (CHART-SF); the Community Integration Questionnaire Version 2 (CIQ-2); the Participation Objective-Participation Subjective (PO-PS) section of the Living Life After TBI (LLATBI); and the Mayo-Portland Participation Index (M2PI). The primary objectives of this study are to: 1) evaluate internal consistency, concurrent validity, and item/scale structure of current measures of community participation after TBI; and 2)... more
Investigators: Whiteneck G, Bushnik T, Cicerone K, Corrigan J, Bogner J, Dijkers M, Gordon W, Hart T, Malec J, Novack T view full
Lead Center: Craig Hospital
Collaborating Centers: University of Alabama, Santa Clara Valley Medical Center, Mayo Medical Center, Kessler Medical Rehabilitation Research and Education Corporation, Mount Sinai School of Medicine, Ohio State University, Moss Rehabilitation Research Institute
Mortality and Life Expectancy After TBI Rehabilitation
Abstract: Abstract from Project Phase I - Objective: To investigate mortality, life expectancy, risk factors for death, and causes of death in individuals with traumatic brain injury (TBI). Methods: Retrospective cohort study utilizing data from the TBI Model Systems National Database, the Social Security Death Index and death certificates. Participants: 2,178 individuals with TBI completing inpatient rehabilitation in one of 15 National Institute on Disability and Rehabilitation Research-funded TBI Model Systems of care between 1988 and 2001. Results: Individuals with TBI were twice as likely to die compared to individuals in the general population of similar age, gender and race, resulting in an estimated average life expectancy reduction of 7... more
Investigators: Harrison-Felix C, Whiteneck G, Devivo M, Hammond F, Jha A view full
Lead Center: Craig Hospital
Collaborating Centers: Carolinas Rehabilitation, Emory University/Shepherd Center, Mayo Medical Center, Ohio State University, University of Alabama, Oregon Health Sciences University, University of Missouri, Moss Rehabilitation Research Institute, Rehabilitation Institute of Michigan, Spaulding Rehabilitation Hospital, Virginia Commonwealth University/Medical College of Virginia, Santa Clara Valley Medical Center, University of Washington
Understanding Outcomes Based on the Post-Acute Hospitalization Pathways Followed by Persons with Traumatic Brain Injury
Abstract: Primary objectives: To identify the factors that determine the pathways of care people with traumatic brain injury (TBI) follow after acute care discharge, and to identify differences in outcome based on those pathways.
Research design: Telephone survey of a statewide, population-based sample of persons surviving through acute hospitalization for TBI.
Methods and procedures: Included were 1059 individuals who: (a) were discharged from acute care in 1996 and 1997; (b) were eligible for inclusion in the statewide, population-based TBI follow-up system, (c) had either a severe TBI or were among a 20% random sample with milder injuries, and (d) consented to participate in a 1-year post-injury follow-up survey. The survey included... more
Investigators: Whiteneck G, Mellick D, Gerhart K view full
Lead Center: Craig Hospital
Evaluation of the Home and Community-based Services Brain Injury Medicaid Waiver Program in Colorado
Abstract: Primary Objectives: To evaluate ColoradoÂ’s Traumatic Brain Injury (TBI) Waiver program in terms of functional, community integration, and other key psychosocial outcomes.

Research Design: Results of telephone surveys of 66 TBI survivors who had received services through the Colorado Medicaid program were compared with those of a matched sample not receiving such services.

Methods and Procedures: Participants were identified by ColoradoÂ’s Medicaid program, and a control group was randomly selected from the population-based Colorado Traumatic Brain Injury Registry and Follow-up System. Groups were matched on Glasgow Coma Scale score at injury, age, gender, whether inpatient rehabilitation had been received, and the number of years... more
Investigators: Gerhart K, Cusick C, Mellick D, Breese P, Towle V, Whiteneck G view full
Lead Center: Craig Hospital
Early Interventions to Preserve Viable Employment Options
Abstract: The ability to return to a previous job has been shown to be a key predictor of job success following traumatic brain injury (TBI); however this outcome is relatively rare. Although many TBI survivors do appear to have jobs waiting for them, early intervention is crucial for their success, even if actual return to work was not planned until much later. Craig Hospital uses an intervention-consultation approach in which rehabilitation specialists provide individualized consultation to help employers and design customized work reintegration plans with gradual buildup of expectations, endurance and complexity. The study hypothesis was that a work reintegration program focusing on early intervention, a return to preinjury employment, and an... more
Investigators: McLaughlin E, Harrison-Felix C, Whiteneck G, Gerber D, Morey C, Cusick C view full
Lead Center: Craig Hospital
The Effect of Aricept® in Persons with Persistent Memory Disorder Following Traumatic Brain Injury: A Pilot Study.
Abstract: PRIMARY OBJECTIVE: To investigate effectiveness of donepezil hydrochloride (Aricept®) in treating persistent memory deficits in persons with traumatic brain injury.

RESEARCH DESIGN: Single subject ABAC design was used so that each participant could serve as their own control.

METHODS AND PROCEDURES: Seven TBI survivors with persistent memory dysfunction, at least 1 ½ years post-injury, underwent two, six-month trials of Aricept®. The following tests were used to assess memory and cognition: Brief Visual Memory Test-Revised (BVMT-R), Hopkins Verbal Learning Test, Digit Span and Letter Number Sequence subtest of the Wechsler Adult Intelligence Scale-III, Controlled Oral Word Association Test, and Memory Functioning... more
Investigators: Cilo M, Morey C, Berry J, Cusick C view full
Lead Center: Craig Hospital
Magnetic resonance imaging of traumatic brain injury: Relationship of T2 SE and T2*GE to clinical severity and outcome
Abstract: Primary objectives: To evaluate (1) the sensitivity of magnetic resonance imaging (MRI) T2* weighted gradient echo (GE) vs T2 weighted spin echo (SE) technology for lesion detection in traumatic brain injury (TBI) and (2) the relationship of lesion patterns to acute clinical severity and 1 year post-injury outcome measures. Research design: Comparative analysis. Methods and procedures: Forty-three acute rehabilitation patients with TBI were imaged utilizing T2 SE and T2* GE techniques an average of 26 days post-injury. Acute clinical severity measures, including Glasgow Coma Scale (GCS), time to follow commands (TFC) and post-traumatic amnesia (PTA) were abstracted from medical records. One-year post-injury outcome measures including... more
Investigators: Gerber D, Weintraub A, Whiteneck G, Cusick C view full
Lead Center: Craig Hospital
A Collaborative National Information Center on Outcome Measurement in Brain Injury
Abstract: In order to better serve the rehabilitation community, the Center on Outcome Measurement in Brain Injury (COMBI) website and newsletter are proposed. The COMBI provides information on measures in a format that is easily accessed and understood, free of charge, objective, and comprehensive. Each measure will have online syllabi, training and testing materials (including the measure's rating form), information on scale properties, a reference listing of published studies using the measure, and a section for "Frequently Asked Questions."... more
Investigators: Bushnik T, Wright J, Mellick D, Harrison-Felix C, Boake C, Sander A, Malec J, Sherer M, Thompson R, Novack T, Dijkers M, Bogner J, Corrigan J, Hammond F, Kreutzer J, Marwitz J, Millis S, O'Neil-Pirozzi T view full
Lead Center: Santa Clara Valley Medical Center
Collaborating Centers: Craig Hospital, The Institute for Rehabilitation and Research, Mayo Medical Center, Methodist Rehabilitation Center, University of Alabama, Rehabilitation Institute of Michigan, Ohio State University, Carolinas Rehabilitation, Virginia Commonwealth University/Medical College of Virginia, Moss Rehabilitation Research Institute, Kessler Medical Rehabilitation Research and Education Corporation, Spaulding Rehabilitation Hospital, Mount Sinai School of Medicine
Family Members' and Caregivers' Emotional Well Being
Abstract: Objectives for this collaborative project include: (1) to examine the frequency and magnitude of emotional distress and depressive symptoms and the level of life satisfaction of family members and non-family caregivers as compared to clinical and non-clinical populations, and (2) to identify the relationships between caregivers' well-being and survivors' injury severity and level of functioning. Six TBI Model System centers are collecting data from family members, significant others, and friends of individuals in the National Database at either 1, 2, or 5 year follow-up. Data is collected from each caregiver only once. Measures include the Neurobehavioral Functioning Inventory (NFI) Depression subscale, the Brief Symptom Inventory-18... more
Investigators: Kreutzer J, Marwitz J, Rapport L, Koviak C, Hammond F, Morita C, Hart T, Selleck E, Glenn M, Harrison-Felix C view full
Lead Center: Virginia Commonwealth University/Medical College of Virginia
Collaborating Centers: Spaulding Rehabilitation Hospital, Rehabilitation Institute of Michigan, Carolinas Rehabilitation, Moss Rehabilitation Research Institute, Craig Hospital
16 project available at this time for Craig Hospital

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National Traumatic Brain Injury Live Syllabus v2.00.00
Registry Dataset accessed Monday, September 25, 2006 5:52am
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