Projects of the TBINDC Registry by Researchers Last Name
| Apolipoprotein E and Cognitive Outcome Following Moderate and Severe Traumatic Brain Injury | ||
| Abstract: Objective: To examine the relationship between the Apolipoprotein E (APOE) 4 allele and cognitive outcome in traumatic brain injured (TBI) patients. It was predicted that the carriers would exhibit significantly poorer cognitive outcomes. Participants: Seventy-four TBI patients 16-59 years old were examined at discharge from inpatient rehabilitation programs. Thirty-nine patients were reassessed at one year follow-up. Settings: Rehabilitation programs at Emory University School of Medicine and Shepherd Center in Atlanta, Georgia, and the Mayo Clinic College of Medicine in Rochester, Minnesota. Methods: Neuropsychological assessments of attention, language, memory, visuoanalytic skills, and executive functioning were... more |
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| Investigators: | Goldstein F, Stringer A, Malec J, Gearing M, Moessner A, Greenspan A, Macciocchi S | view full details |
| Lead Center: | Mayo Medical Center | |
| Apolipoprotein E Genotype and Outcome Following TBI | ||
| Abstract: Investigations suggest a link between the ApoE e4 allele, a genetic risk factor for AlzheimerÂ’s disease and outcome from brain injury. ApoE e4 is associated with excessive beta amyloid protein deposits in autopsy studies of severe brain injury. Animal studies demonstrate the role of ApoE in neuronal repair after head injury. ApoE-deficient brain injured mice are less able to produce antioxidant reducing substances than control mice, and exhibit more pronounced motor and spatial memory deficits. To date, there have been no prospective investigations examining patients over time to determine whether ApoE e4 is a risk factor for decreased recovery following brain injury. A prospective, longitudinal study is proposed, with patients... more | ||
| Investigators: | Goldstein F, Gearing M, Greenspan A, Stringer A | view full details |
| Lead Center: | Emory University/Shepherd Center | |
| Is APOE Status Predictive of Functional Outcome Following Moderate-Severe Traumatic Brain Injury? | ||
| Abstract: The predictive power of apolipoprotein E (APOE) genotype (E2 and E4 status) on traumatic brain injury (TBI) outcome was examined in the largest study of this association to-date. One hundred forty-six individuals with moderate to severe TBI underwent APOE genotyping. Functional outcome was assessed with the Disability Rating Scale, the Functional Independence Measure, and the Living and Vocational Independence Scale. Injury severity predicted outcome at discharge and follow-up. Neither E2 nor E4 status predicted additional variance in outcome at either recoverytime-point. Contrary to previously reported findings, results do not suggest a directassociation between APOE genotype and acute or long-term functional outcomes following TBI. ... more | ||
| Investigators: | Malec J, Goldstein F, Stringer A, Greenspan A, Macciocchi S, Gearing M, Brown A, Moessner A | view full details |
| Lead Center: | Mayo Medical Center | |
| The Role of Progesterone in Functional Recovery Following Moderate and Severe TBI | ||
| Abstract: Compelling evidence from animal studies suggest that progesterone plays a role in reducing neuronal damage and enhancing functional recovery by attenuating cerebral edema, blunting cytotoxic events, and facilitating neuronal recovery. However, the role of progesterone in brain recovery has not yet been studied in humans. If progesterone is found to reduce secondary consequences of brain injury and to result in improved outcomes in humans, then use of exogenous progesterone could prove to be an effective early intervention following brain injury. A prospective cohort study design with a match control group will be used to compare and male and female recovery from brain injury and to determine the role of progesterone in recovery of... more | ||
| Investigators: | Greenspan A, Stringer A, Goldstein F, Wright D, Stein D | view full details |
| Lead Center: | Emory University/Shepherd Center | |
