Projects of the TBINDC Registry by Researchers Last Name
8 projects available at this time for David Burke, M.D.

Sleep wake cycles of those with brain injury
Abstract: This study involved a retrospective review of medical records to determine the severity of sleep disturbance among individuals with brain injury. Data on 17 patients was recorded hourly for a two-week period by staff as to the wakefulness of the patients. In addition, demographic data and FIM scores were collected. Results indicated that the 17 patients experienced interrupted sleep during 71% of the night. This was true of 66% of the patients with traumatic brain injury and 92% of the patients with anoxic brain injury. 100% of the women had a sleep disturbance compared with 64% of the men. Patients who were 60+ years of age had interrupted sleep 90% of the time compared with those who were less than 25 years of age (70%). FIM scores... more
Investigators: Burke D, Shah M, Schneider J, Ahanger B, Al-Adawi S view full
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Lead Center: Spaulding Rehabilitation Hospital
Subacute changes in metabolism following TBI
Abstract: Objectives: 1) to determine whether patients with recent TBI entering a rehabilitation facility are dehydrated, malnourished, and/or have an increased resting metabolic rate; 2) to determine whether resting metabolic rate is associated with severity of TBI; 3)to determine the duration of metabolic changes seen in BI patients admitted to a rehabilitation facility. Patient Population: Patients admitted to the inpatient TBI unit at SRH for treatment of head trauma. Methods: Patients had their caloric expenditure measured three times: once upon admission, and two times during their first week of stay. Resting energy expenditure data will be obtained using a portable metabolic unit (Cosmed, K4b2, Rome, Italy). Results: Data was collected on 21... more
Investigators: Burke D view full
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Lead Center: Spaulding Rehabilitation Hospital
Brain injury severity as measured by the Glasgow Coma Scale & its influence on outcome as measured by Disability Rating Scale at acute rehabilitation discharge and long term follow-up after severe TBI
Abstract: This study will compare outcomes among those with severe injuries to determine how they differ at discharge from rehabilitation and at 1, 5 and 10 years after injury. The data from the model system national database will be reviewed to determine how the patterns and ultimate recovery differ by Glasgow Coma Scale (GCS) score. Severity of injury will be measured by GCS scores in the emergency room. Outcome will be measured by the Disability Rating Scale (DRS).... more
Investigators: Burke D, Hammond F, Rosenthal M, Glenn M, Meythaler J, Jacob L view full
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Lead Center: Spaulding Rehabilitation Hospital
Collaborating Centers: Charlotte Institute of Rehabilitation, University of Alabama
The development of a scale for the measurement of apathy following brain injury
Abstract: The investigators sought to develop a valid and reliable scale to measure apathy following brain injury. They adapted a number of apathy items from other scales, made up new items, including confounder items, categorized the items into domains, and interviewed therapists regarding the comprehensibility of the items. The next steps will be factor analysis, pilot administration by therapists, and then validity and reliability studies.... more
Investigators: Glenn M, Burke D, O'Neil-Pirozzi T, Goldstein R, Jacob L, Selleck E view full
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Lead Center: Spaulding Rehabilitation Hospital
Validation of the Designation "Apathetic" on the Apathy Evaluation Scale
Abstract: 45 outpatients with TBI completed the AES-S. 37 family members, friends, or significant others filled out the AES-I. Three clinicians prospectively gave a blind impression of the presence or absence of apathy and retrospectively described his/her perception of the subjectÂ’s apathy on a seven-point subjective rating scale. No cutoff score on the AES-S or AES-I was found to have reasonable sensitivity and specificity with respect to the ability to predict the clinician's designation of a subject as apathetic... more
Investigators: Glenn M, Burke D, O'Neil-Pirozzi T, Goldstein R, Kettell J view full
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Lead Center: Spaulding Rehabilitation Hospital
Depression Following TBI
Abstract: 41 outpatients with TBI filled out the Beck Depression Inventory-II (BDI-II). 24 of 41 subjects (59%) scored in the depressed categories based on BDI-II scores >13. 14 (34%) scored in the moderate or severe depression categories (BDI>19). Logistic regression demonstrated a positive relationship among depression and age, female gender, and mild TBI; and a negative relationship between depression and violent etiology of injury. ANOVA demonstrated that individuals with mild TBI were significantly older than those with moderate or severe TBI, which might account for the association between depression and age... more
Investigators: Glenn M, Burke D, O'Neil-Pirozzi T, Goldstein R, Jacob L view full
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Lead Center: Spaulding Rehabilitation Hospital
Regional Cerebral Activation on fMRI as a Predictor of Outcome Following Traumatic Brain Injury
Abstract: Using functional magnetic resonance imaging (fMRI), this TBIMS project is studying memory rehabilitation in the traumatic brain injury (TBI) population. The study includes both cross-sectional and longitudinal components. The cross-sectional component is assessing regional cerebral activity during word list memorization between subjects with TBI and matched healthy controls. The longitudinal component is assessing the ability of fMRI to predict outcome among persons with TBI from
a custom-designed memory rehabilitation program.... more
Investigators: Strangman G, O'Neil-Pirozzi T, Burke D, Cristina D, Goldstein R, Katz D, Rauch S, Savage C, Glenn M view full
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Lead Center: Spaulding Rehabilitation Hospital
Serial Casting Versus Ultrasound with Weight Bearing for the Treatment of Equinovarus Contractures in the Individual with Acute TBI: Comparison of Efficacy and Cost
Abstract: Plantar flexion contractures are a common complication of TBI. Multiple treatment methods are available for increasing joint range of motion (ROM). Serial casting and ultrasound combined with a static stretch are two conservative methods of treatment for plantar flexion contractures known to increase dorsiflexion ROM. However, studies have not compared the effectiveness and cost of serial casting versus ultrasound/static stretch in increasing dorsiflexion ROM. This is a randomized, controlled study comparing the efficacy and cost associated with these two methods... more
Investigators: Hammond F, Lang E, LaBarbera J, Bucklew S, Norton H, Burke D, Flanagan S, Rupright J view full
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Lead Center: Charlotte Institute of Rehabilitation
Collaborating Centers: Spaulding Rehabilitation Hospital, University of Missouri
8 projects available at this time for David Burke, M.D.




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